Publication | Cancer/DNA damage Lab.

2024

Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation

Won Chan Hwang, Kibeom Park Silvia Park, Na Young Cheon, Ja Yil Lee, Taejoo Hwang, Semin Lee, Jong-Mi Lee, Min Kyung Ju, Joo Rak Lee, Yong-Rim Kwon, Woo-Lam Jo, Myungshin Kim*, Yoo-Jin Kim*, Hongtae Kim* Leukemia. 2024 Mar 21. doi: 10.1038/s41375-024-02228-4. (*Corresponding Author)

https://pubmed.ncbi.nlm.nih.gov/38514771/

REXO5 promotes genomic integrity through regulating R-loop using its exonuclease activity

Ye Jin Lee, Seo Yun Lee, Soo-hyun Kim, Soo Hyeon Lee, Sungho Park, Jae Jin Kim*, Dong-Wook Kim*, Hongtae Kim* Leukemia. 2024 July 30. doi: 10.1038/s41375-024-02362-z (*Corresponding Author)

https://pubmed.ncbi.nlm.nih.gov/39080354/

2023

ZNF212 promotes genomic integrity through direct interaction with TRAIP

Hee Jin Chung, Joo Rak Lee, Tae Moon Kim, Soomi Kim, Kibeom Park, Myung-Jin Kim, Eunyoung Jung, Subin Kim, Eun A Lee, Jae Sun Ra, Sunyoung Hwang, Ja Yil Lee, Orlando D Schärer, Yonghwan Kim*, Kyungjae Myung*, Hongtae Kim* Nucleic Acids Res. 2023 Jan 3;gkac1226. doi: 10.1093/nar/gkac1226. (*Corresponding Author)

https://pubmed.ncbi.nlm.nih.gov/36594163/

Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase

Yujin Kang, Ye Gi Han, Keon Woo Khim, Woo Gyun Choi, Min Kyung Ju, Kibeom Park, Kyeong Jin Shin, Young Chan Chae, Jang Hyun Choi*, Hongtae Kim*, Ja Yil Lee* Nucleic Acids Res. 2023 Jun 28;gkad543. doi: 10.1093/nar/gkad543. (*Corresponding Author)

https://pubmed.ncbi.nlm.nih.gov/37378431/

2022

PWWP2B promotes DNA end resection and homologous recombination

Min Kyung Ju, Joo Rak Lee, Yeonsong Choi, Seon Young Park, Hee Jung Sul, Hee Jin Chung, Soyeong An, Semin Lee, Eunyoung Jung, Bohyun Kim, Bo Youn Choi, Bum Jun Kim, Hyeong Su Kim, Hyun Lim, Ho Suk Kang, Jae Seung Soh, Kyungjae Myung, Kab Choong Kim, Ji Woong Cho, Jinwon Seo, Tae Moon Kim, Ja Yil Lee, Yonghwan Kim*, Hongtae Kim*, Dae Young Zang* EMBO Rep. 2022 May 18;e53492. doi: 10.15252/embr.202153492. (*Corresponding Author)

https://pubmed.ncbi.nlm.nih.gov/35582821/

Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia

Kibeom Park, Hee-Seop Yoo, Chang-Kyu Oh, Joo Rak Lee, Hee Jin Chung, Ha-Neul Kim, Soo-Hyun Kim, Kyung-Mi Kee, Tong Yoon Kim, Myungshin Kim, Byung-Gyu Kim, Jae Sun Ra, Kyungjae Myung, Hongtae Kim, Seung Hun Han, Min-Duk Seo, Yoonsung Lee, Dong-Wook Kim Cancer Med . 2022 Mar 30. doi: 10.1002/cam4.4727

https://pubmed.ncbi.nlm.nih.gov/35352878/

2021

NSMF promotes the replication stress-induced DNA damage response for genome maintenance.

Min Kyung Ju, Kyeong Jin Shin, Joo Rak Lee, Keon Woo Khim, Eun A Lee, Jae Sun Ra, Byung-Gyu Kim, Han-Seul Jo, Jong Hyuk Yoon, Tae Moon Kim, Kyungjae Myung, Jang Hyun Choi*, Hongtae Kim*, Young Chan Chae* Nucleic Acids Res. 2021 May 8;gkab311. doi: 10.1093/nar/gkab311.(*Corresponding Author)

https://pubmed.ncbi.nlm.nih.gov/33963872/

USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing

Jae Jin Kim, Seo Yun Lee, Yiseul Hwang, Soyeon Kim, Jee Min Chung, Sangwook Park, Junghyun Yoon, Hansol Yun, Jae-Hoon Ji, Sunyoung Chae, Hyeseong Cho, Chan Gil Kim, Ted M Dawson, Hongtae Kim*, Valina L Dawson*, Ho Chul Kang* Nucleic Acids Res. 2021 Nov 8;49(19):11083-11102. doi: 10.1093/nar/gkab892. (*Corresponding Author)

https://pubmed.ncbi.nlm.nih.gov/34614178/

2019

GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia.

Han SH, Korm S, Han YG, Choi SY, Kim SH, Chung HJ, Park K, Kim JY, Myung K, Lee JY, Kim H*, Kim DW*.Autophagy. 2019 Dec;15(12):2076-2090. doi: 10.1080/15548627.2019.1596492. Epub 2019 Mar 30.PMID: 30929559 (*Corresponding Author)

https://pubmed.ncbi.nlm.nih.gov/30929559/

TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways.

Han YG, Yun M, Choi M, Lee SG, Kim H.Oncol Rep. 2019 Jun;41(6):3305-3312. doi: 10.3892/or.2019.7092. Epub 2019 Apr 2.PMID: 30942468

https://pubmed.ncbi.nlm.nih.gov/30942468/

INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification.

Sohn SH, Kim B, Sul HJ, Kim YJ, Kim HS, Kim H, Seo JB, Koh Y, Zang DY.BMC Res Notes. 2019 Mar 11;12(1):125. doi: 10.1186/s13104-019-4163-x.PMID: 30871613

https://pubmed.ncbi.nlm.nih.gov/30871613/

Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia.

Chang HR, Cho SY, Lee JH, Lee E, Seo J, Lee HR, Cavalcanti DP, Mäkitie O, Valta H, Girisha KM, Lee C, Neethukrishna K, Bhavani GS, Shukla A, Nampoothiri S, Phadke SR, Park MJ, Ikegawa S, Wang Z, Higgs MR, Stewart GS, Jung E, Lee MS, Park JH, Lee EA, Kim H, Myung K, Jeon W, Lee K, Kim D, Kim OH, Choi M, Lee HW, Kim Y, Cho TJ.Am J Hum Genet. 2019 Mar 7;104(3):439-453. doi: 10.1016/j.ajhg.2019.01.009. Epub 2019 Feb 14.PMID: 30773278 Free PMC article.

https://pubmed.ncbi.nlm.nih.gov/30773278/#affiliation-16

2018

Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation

Lee, Nam Soo, Chang, Hae Ryung, Kim, Soomi, Ji, Jae-Hoon, Lee, Joorak, Lee, Hyun Ji, Seo, Yoojeong, Kang, Misun, Han, Joo Seok, Myung, Kyungjae, Kim, Yonghwan, Kim, Hongtae . J Biol Chem .2018 Jan 12;293(2):588-598. doi: 10.1074/jbc.M116.765602. Epub 2017 Nov 22.

https://pubmed.ncbi.nlm.nih.gov/29167269/

2017

RAP80 binds p32 to preserve the functional integrity of mitochondria

Chung, Hee Jin, Korm, Sovannarith, Lee, Se-In, Phorl, Sophors, Noh, Solhee, Han, Miae, Naskar, Rema, Kim, Hongtae, Lee, Joo-Yon BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017 Oct 21;492(3):441-446.doi:10.1016/j.bbrc.2017.08.077. Epub 2017 Aug 24.

https://pubmed.ncbi.nlm.nih.gov/28842250/

Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia

Han, SH, Kim, SH, Kim, HJ, Lee, Y, Choi, SY, Park, G, Kim, DH, Lee, A, Kim, J, Choi, JM, Kim, Y, Myung, Kyungjae, Kim, Hongtae*, Kim, DW*. Leukemia . 2017 Jul;31(7):1532-1539. doi: 10.1038/leu.2017.72. Epub 2017 Feb 24. (*Corresponding Author)

https://pubmed.ncbi.nlm.nih.gov/28232743/

2016

Phosphorylation of Astrin Regulates Its Kinetochore Function

Chung, Hee Jin, Park, Ji Eun, Lee, Nam Soo, Kim, Hongtae, Jang, Chang-Young JOURNAL OF BIOLOGICAL CHEMISTRY, v.291, no.34, pp.17579-17592 J Biol Chem . 2016 Aug 19;291(34):17579-92. doi: 10.1074/jbc.M115.712745. Epub 2016 Jun 20.

https://pubmed.ncbi.nlm.nih.gov/27325694/

Factors forming the BRCA1-A complex orchestrate BRCA1 recruitment to the sites of DNA damage

Her, Joonyoung, Lee, Nam Soo, Kim, Yonghwan, Kim, Hongtae Acta Biochim Biophys Sin (Shanghai). 2016 Jul;48(7):658-64. doi: 10.1093/abbs/gmw047. Epub 2016 Jun 20.

https://pubmed.ncbi.nlm.nih.gov/27325824/

RAP80 regulates epithelial-mesenchymal transition related with metastasis and malignancy of cancer

Park, Song Yi, Korm, Sovannarith, Chung, Hee Jin, Choi, Su Jin, Jang, Jin-Ju, Cho, Sunhee, Lim, Yong Taik, Kim, Hongtae, Lee, Joo-Yong Acta Biochim Biophys Sin (Shanghai). 2016 Jul;48(7):658-64. doi: 10.1093/abbs/gmw047. Epub 2016 Jun 20.

https://pubmed.ncbi.nlm.nih.gov/27325824/

SUMOylation regulates nuclear localization and stability of TRAIP/RNF206

Park, I. Seul, Han, Ye Gi, Chung, Hee Jin, Jung, Yong Woo, Kim, Yonghwan, Kim, Hongtae Biochem Biophys Res Commun. 2016 Feb 19;470(4):881-7. doi: 10.1016/j.bbrc.2016.01.141. Epub 2016 Jan 25.

https://pubmed.ncbi.nlm.nih.gov/26820530/

TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage

Lee, Nam Soo, Chung, Hee Jin, Kim, Hyoung-June, Lee, Seo Yun, Ji, Jae-Hoon, Seo, Yoojeong, Han, Seung Hun, Choi, Minji, Yun, Miyong, Lee, Seok-Geun, Myung, Kyungjae, Kim, Yonghwan, Kang, Ho Chul , Kim, Hongtae Nat Commun. 2016 Jan 19;7:10463. doi: 10.1038/ncomms10463.

https://pubmed.ncbi.nlm.nih.gov/26781088/

Interactome Analysis Reveals that Heterochromatin Protein 1 gamma (HP1 gamma) Is Associated with the DNA Damage Response Pathway

Kim, Hongtae, Choi, Jae Duk, Kim, Byung-Gyu, Kang, Ho Chul, Lee, Jong-Soo Cancer Res Treat. 2016 Jan; 48(1): 322–333. Published online 2015 Mar 6. doi: 10.4143/crt.2014.294

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720079/

2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis

Lim, Sangho, Kim, Won-Ju, Kim, Yeon-Ho, Lee, Sohee, Koo, Ja-Hyun, Lee, Jung-Ah, Yoon, Heeseok, Kim, Do-Hyun, Park, Hong-Jai, Kim, Hye-Mi, Lee, Hong-Gyun, Kim, Ji Yun, Lee, Jae-Ung, Shin, Jae Hun, Kim, Lark Kyun, Doh, Junsang, Kim, Hongtae, Lee, Sang-Kyou, Bothwell, Alfred L. M., Suh, Minah, Choi, Je-Min Nat Commun. 2015; 6: 8244. Published online 2015 Sep 15. doi: 10.1038/ncomms9244

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579786/

HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation

Kim, Hak-June, Nagano, Yoshito, Choi, Su Jin, Park, Song Yi, Kim, Hongtae, Yao, Tso-Pang, Lee, Joo-Yong Biochem Biophys Res Commun. 2015 Sep 4;464(4):1235-1240. doi: 10.1016/j.bbrc.2015.07.111. Epub 2015 Jul 23.

https://pubmed.ncbi.nlm.nih.gov/26210454/

Dimerization of TRAF-interacting protein (TRAIP) regulates the mitotic progression

Park, I. Seul, Jo, Ku-Sung, Won, Hyung-Sik, Kim, Hongtae. Biochem Biophys Res Commun . 2015 Aug 7;463(4):864-9. doi: 10.1016/j.bbrc.2015.06.026. Epub 2015 Jun 18.

https://pubmed.ncbi.nlm.nih.gov/26093298/

Micelle-templated dendritic gold nanoparticles for enhanced cellular delivery of siRNA

Lee, Min Sang, Kim, Nak Won, Lee, Jung Eun, Lim, Dong Woo, Suh, Wonhee, Kim, Hong Tae, Park, Ji Won, Jeong, Ji Hoon MACROMOLECULAR RESEARCH, v.23, no.7, pp.670-677

link.springer.com/article/10.1007/s13233-015-3091-4

In vitro development of canine somatic cell nuclear transfer embryos in different culture media

Kim, Dong-Hoon, No, Jin-Gu, Choi, Mi-Kyung, Yeom, Dong-Hyeon, Kim, Dong-Kyo, Yang, Byoung-Chul, Yoo, Jae Gyu, Kim, Min Kyu, Kim, Hong-Tea J Vet Sci. 2015 Jun; 16(2): 233–235. Published online 2015 Jun 17. doi: 10.4142/jvs.2015.16.2.233

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483508/

Molecular determinants of polyubiquitin recognition by continuous ubiquitin-binding domains of Rad18

Trung Thanh Thach, Lee, Namsoo, Shin, Donghyuk, Han, Seungsu, Kim, Gyuhee, Kim, Hongtae, Lee, Sangho Biochemistry. 2015 Mar 31;54(12):2136-48. doi: 10.1021/bi5012546. Epub 2015 Mar 19.

https://pubmed.ncbi.nlm.nih.gov/25756347/

Pin1 Promotes Neuronal Death in Stroke by Stabilizing Notch Intracellular Domain

Baik, Sang-Ha, Fane, Mitchell, Park, Joon Hyung, Cheng, Yi-Lin, Fann, David Yang-Wei, Yun, Ui Jeong, Choi, Yuri, Park, Jong-Sung, Chai, Bing Han, Park, Jin Su, Back, Seung Hyun, Jeong, Jae In, Jang, Ye Jin, Bahn, Gahee, Lee, Joo-Yong, Li, Yu-I, Sobey, Christopher G., Uchida, Takafumi, Park, Jae Hyung, Kim, Hong Tae, Tang, Sung-Chun, Arumugam, Thiruma V., Jo, Dong-Gyu Ann Neurol. 2015 Mar;77(3):504-16. doi: 10.1002/ana.24347. Epub 2015 Feb 3.

https://pubmed.ncbi.nlm.nih.gov/25558977/

2014

Epigallocatechin-3-O-(3-O-methyl)-gallate-induced Differentiation of Human Keratinocytes Involves Klotho-Mediated Regulation of Protein Kinase-cAMP Responsive Element-Binding Protein Signaling

Kim, Hyoung-June, Chang, Huikyoung, Han, Seung Hun, Lee, Min Seuk, Jung, Ji-Yong, An, SoonAe, Baek, Seok-Yun, Lee, Jin Ho, Lee, John Hwan, Lee, Tae Ryong, Shin, Dong Wook, Kim, Hongtae Int J Mol Sci. 2014 Apr; 15(4): 5749–5761. Published online 2014 Apr 4. doi: 10.3390/ijms15045749

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013593/

2013

Overexpression of a novel regulator of p120 catenin, NLBP, promotes lung adenocarcinoma proliferation

Kim, Chang Hee, Nam, Hae-Seong, Lee, Eun Hee, Han, Seung Hun, Cho, Hyun Jung, Chung, Hee Jin, Lee, Nam Soo, Choi, Suk Jin, Kim, Hojoong, Ryu, Jeong Seon, Kwon, Junhye, Kim, Hongtae Cell Cycle . 2013 Aug 1;12(15):2443-53. doi: 10.4161/cc.25451. Epub 2013 Jun 28.

https://pubmed.ncbi.nlm.nih.gov/23839039/

Enhanced Transfection by Antioxidative Polymeric Gene Carrier that Reduces Polyplex-Mediated Cellular Oxidative Stress

Lee, Min Sang, Kim, Nak Won, Lee, Kyuri, Kim, Hongtae, Jeong, Ji Hoon Pharm Res. 2013 Jun;30(6):1642-51. doi: 10.1007/s11095-013-1009-4. Epub 2013 Mar 30.

https://pubmed.ncbi.nlm.nih.gov/23543301/

2012

Cdk1 Protein-mediated Phosphorylation of Receptor-associated Protein 80 (RAP80) Serine 677 Modulates DNA Damage-induced G(2)/M Checkpoint and Cell Survival

Cho, Hyun Jung, Oh, Yun Jung, Han, Seung Hun, Chung, Hee Jin, Kim, Chang Hee, Lee, Nam Soo, Kim, Won-Ju, Choi, Je-Min, Kim, Hongtae J Biol Chem. 2013 Feb 8;288(6):3768-76. doi: 10.1074/jbc.M112.401299. Epub 2012 Dec 21.

https://pubmed.ncbi.nlm.nih.gov/23264621/

Cell-penetrating peptide mimicking polymer-based combined delivery of paclitaxel and siRNA for enhanced tumor growth suppression

Jang, Yeon Lim, Yun, Ui Jeong, Lee, Min Sang, Kim, Myung Goo, Son, Sohee, Lee, Kyuri, Chae, Su Young, Lim, Dong Woo, Kim, Hong Tae, Kim, Sun Hwa, Jeong, Ji Hoon Int J Pharm. 2012 Sep 15;434(1-2):488-93. doi: 10.1016/j.ijpharm.2012.04.083. Epub 2012 May 14.

https://pubmed.ncbi.nlm.nih.gov/22613208/

Degradation of human RAP80 is cell cycle regulated by Cdc20 and Cdh1 ubiquitin ligases

Cho, Hyun Jung, Lee, Eun Hee, Han, Seung Hun, Chung, Hee Jin, Jeong, Ji Hoon, Kwon, Junhye, Kim, Hongtae Mol Cancer Res. 2012 May;10(5):615-25. doi: 10.1158/1541-7786.MCR-11-0481. Epub 2012 Mar 16.

https://pubmed.ncbi.nlm.nih.gov/22426463/

RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage

Liu, Ting, Chen, Hongxia, Kim, Hongtai, Huen, Michael S. Y., Chen, Junjie, Huang, Jun DNA Repair (Amst). Author manuscript; available in PMC 2013 Sep 20. Published in final edited form as: DNA Repair (Amst). 2012 Feb 1; 11(2): 131–138. Published online 2011 Oct 28. doi: 10.1016/j.dnarep.2011.10.012

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779126/

2011

Notch1 binds and induces degradation of Snail in hepatocellular carcinoma

Lim, Seung-Oe, Kim, Hyeon Seop, Quan, Xiaoyuan, Ahn, Sun-Min, Kim, Hongtae, Hsieh, David, Seong, Je Kyung, Jung, Guhung BMC Biol. 2011 Nov 30;9:83. doi: 10.1186/1741-7007-9-83.

https://pubmed.ncbi.nlm.nih.gov/22128911/

Energy-Independent Intracellular Gene Delivery Mediated by Polymeric Biomimetics of Cell-Penetrating Peptides

Chae, Su Young, Kim, Hyun June, Lee, Min Sang, Jang, Yeon Lim, Lee, Yuhan, Lee, Soo Hyeon, Lee, Kyuri, Kim, Sun Hwa, Kim, Hong Tae, Chi, Sang-Cheol, Park, Tae Gwan, Jeong, Ji Hoon Macromol Biosci. 2011 Sep 9;11(9):1169-74. doi: 10.1002/mabi.201100088. Epub 2011 Jul 28.

https://pubmed.ncbi.nlm.nih.gov/21800428/

Coiled-Coil Domain-Containing Protein 98 (CCDC98) Regulates Cyclin B1 Expression by Affecting WTAP Protein Stability

Oh, Yun Jung, Lee, Eun Hee, Lee, Il Kyu, Kim, Kyung-Soo, Kim, Hongtae 생명과학회지 21(8), 2011.8, 1067-1075(9 pages) Journal of Life Science 21(8), 2011.8, 1067-1075(9 pages

https://www.dbpia.co.kr/pdf/pdfView.do?nodeId=NODE01678514&mark=0&useDate=&bookmarkCnt=0&ipRange=N&accessgl=Y&language=ko_KR

Polyethylenimine-g-poly(lactic-co-glycolic acid) as non-toxic micelle-type carrier for gene delivery

Lee, Min Sang, Kim, Myung Goo, Jang, Yeon Lim, Lee, Kyuri, Kim, Taek Gyoung, Kim, Sun Hwa, Park, Tae Gwan, Kim, Hong Tae, Jeong, Ji Hoon Macromolecular Research volume 19, pages688–693(2011)

https://link.springer.com/article/10.1007/s13233-011-0715-1

2010

c-Myc Stimulates Cell Invasion by Inhibiting FBX8 Function

Cho, Hyun Jung, Oh, Yun Jeong, Kwon, Junhye, Kwon, Jae Young, Kim, Kyung-Soo, Kim, Hongtae Mol Cells . 2010 Oct;30(4):355-62. doi: 10.1007/s10059-010-0134-8. Epub 2010 Sep 10.

https://pubmed.ncbi.nlm.nih.gov/20848231/

p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma

Lim, Seung-Oe, Kim, Hongtae, Jung, GuhungFEBS Lett. 2010 Jun 3;584(11):2231-6. doi: 10.1016/j.febslet.2010.04.006. Epub 2010 Apr 10.

https://pubmed.ncbi.nlm.nih.gov/20385133/

MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells

Lim, Jung Yeon, Oh, Ji Hyeon, Jung, Ju Ri, Kim, Seong Muk, Ryu, Chung Hun, Kim, Hong-Tae, Jeun, Sin-Soo J Neurooncol. 2010 May;97(3):339-46. doi: 10.1007/s11060-009-0036-9. Epub 2009 Oct 28.

https://pubmed.ncbi.nlm.nih.gov/19862483/

A Novel LZAP-binding Protein, NLBP, Inhibits Cell Invasion

Kwon, Junhye, Cho, Hyun Jung, Han, Seung Hun, No, Jin Gu, Kwon, Jae Young, Kim, Hongtae J Biol Chem. 2010 Apr 16; 285(16): 12232–12240. Published online 2010 Feb 17. doi: 10.1074/jbc.M109.065920

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852962/

2009

The linker connecting the tandem ubiquitin binding domains of RAP80 is critical for lysine 63-linked polyubiquitin-dependent binding activity

Cho, Hyun-Jung, Lee, Sangho, Kim, Hongtae BMB Rep. 2009 Nov 30;42(11):764-8. doi: 10.5483/bmbrep.2009.42.11.764.

https://pubmed.ncbi.nlm.nih.gov/19944020/

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

Huang, Jun, Huen, Michael S. Y., Kim, Hongtae, Leung, Charles Chung Yun, Glover, J. N. Mark, Yu, Xiaochun, Chen, Junjie Nat Cell Biol. Author manuscript; available in PMC 2009 Nov 1. Published in final edited form as: Nat Cell Biol. 2009 May; 11(5): 592–603. Published online 2009 Apr 26. doi: 10.1038/ncb1865

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743127/

2008

Effect of BRCA1 Haplotype on Survival of Non-Small-Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy

Kim, Hong-Tae, Lee, Jong-Eun, Shin, Eun-Soon, Yoo, Yeon-Kyeong, Cho, Jae-Hwa, Yun, Min-Hye, Kim, Yeul-Hong, Kim, Se-Kyu, Kim, Hyun-Jung, Jang, Tae-Won, Kwak, Seung-Min, Kim, Chul-Soo, Ryu, Jeong-Seon J Clin Oncol. 2008 Dec 20;26(36):5972-9. doi: 10.1200/JCO.2008.16.6496. Epub 2008 Nov 17.

https://pubmed.ncbi.nlm.nih.gov/19018088/

New players in the BRCA1-mediated DNA damage responsive pathway

Kim, Hongtae, Chen, Junjie Mol Cells. Author manuscript; available in PMC 2013 Dec 27. Published in final edited form as: Mol Cells. 2008 Jun 30; 25(4): 457–461. Published online 2008 Apr 24.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873642/

2007

c-Myc interacts with TRF1/PIN2 and regulates telomere length

Kim, Hongtae, Chen, Junjie Biochem Biophys Res Commun. 2007 Nov 3;362(4):842-7. doi: 10.1016/j.bbrc.2007.08.064. Epub 2007 Aug 22.

https://pubmed.ncbi.nlm.nih.gov/17765874/

CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

Kim, Hongtae, Huang, Jun, Chen, Junjie Nat Struct Mol Biol. 2007 Aug;14(8):710-5. doi: 10.1038/nsmb1277. Epub 2007 Jul 22.

https://pubmed.ncbi.nlm.nih.gov/17643122/

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

Kim, Hongtae, Chen, Junjie, Yu, Xiaochun Science. 2007 May 25;316(5828):1202-5. doi: 10.1126/science.1139621.

https://pubmed.ncbi.nlm.nih.gov/17525342/

2005

Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein

Lim, Jung Yeon, Kim, Hongtae, Jeun, Sin-Soo, Kang, Seok-Gu, Lee, Kyung-Jin Biochem Biophys Res Commun. 2006 Feb 24;340(4):1151-7. doi: 10.1016/j.bbrc.2005.12.122. Epub 2005 Dec 28.

https://pubmed.ncbi.nlm.nih.gov/16405865/

The phosphorylation status of merlin is important for regulating the Ras-ERK pathway

Jung, JR, Kim, H, Jeun, SS, Lee, JY, Koh, EJ, Ji, C. Mol Cells 2005 Oct 31;20(2):196-200.

https://pubmed.ncbi.nlm.nih.gov/16267393/

The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity

Ryu, Chung Hun, Kim, Sae-Woong, Lee, Kyu Hwa, Lee, Joo Yong, Kim, Hongtae, Lee, Woon Kyu, Choi, Byung Hyune, Lim, Young, Kim, Young Hoon, Lee, Kweon-Haeng, Hwang, Tae-Kon, Jun, Tae-Youn, Rha, Hyoung Kyun Oncogene. 2005 Aug 11;24(34):5355-64. doi: 10.1038/sj.onc.1208633.

https://pubmed.ncbi.nlm.nih.gov/16007223/

2004

MAP, a protein interacting with a tumor suppressor, merlin, through the run domain

Lee, Il Kyu, Kim, Kyung-Soo, Kim, Hongtae, Lee, Joo Yong, Ryu, Chung Hun, Chun, Heung Jae, Lee, Kyoung-Uk, Lim, Young, Kim, Young Hoon, Huh, Pil-Woo, Lee, Kweon-Haeng, Han, Sang-Ick, Jun, Tae-Youn, Rha, Hyoung Kyun Biochem Biophys Res Commun. 2004 Dec 17;325(3):774-83. doi: 10.1016/j.bbrc.2004.10.095.

https://pubmed.ncbi.nlm.nih.gov/15541357/

Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity

Lee, Joo Yong, Kim, Hongtae, Ryu, Chung Hun, Kim, Jae Young, Choi, Byung Hyune, Lim, Young, Huh, Pil-Woo, Kim, Young-HoonH, Lee, Kweon-Haeng, Jun, Tae-Youn, Rha, Hyung Kyun, Kang, Joon-Ki, Choi, Chang Rak J Biol Chem. 2004 Jul 16;279(29):30265-73. doi: 10.1074/jbc.M312083200. Epub 2004 Apr 27

https://pubmed.ncbi.nlm.nih.gov/15123692/

Merlin neutralizes the inhibitory effect of Mdm2 on p53

Kim, Hongtae, Kwak, Noh-Jin, Lee, Joo Yong, Choi, BH, Lim, Y, Ko, YJ, Kim, YH, Huh, PW, Lee, KH, Rha, HK, Wang, YP J Biol Chem. 2004 Feb 27;279(9):7812-8. doi: 10.1074/jbc.M305526200. Epub 2003 Dec 16.

https://pubmed.ncbi.nlm.nih.gov/14679203/

2003

Amyloid beta peptide (A beta 42) activates PLC-delta 1 promoter through the NF-kappa B binding site

Kim, Jin Young, Kim, Hongtae, Lee, Seok Geun, Choi, Byung Hyune, Kim, Young Hoon, Huh, Pil-Woo, Lee, Kweon-Haeng, Han, Hoon, Rha, Hyoung Kyun Biochem Biophys Res Commun. 2003 Oct 24;310(3):904-9. doi: 10.1016/j.bbrc.2003.09.100.

https://pubmed.ncbi.nlm.nih.gov/14550290/

Merlin suppresses the SRE-dependent transcription by inhibiting the activation of Ras-ERK pathway

Lim, Jung Yeon, Kim, Hongtae, Kim, Young Hoon, Kim, Sae Woong, Huh, Pil-Woo, Lee, Kweon-Haeng, Jeun, Sin-Soo, Rha, Hyoung-Kyun, Kang, Joon-KiBiochem Biophys Res Commun. 2003 Mar 7;302(2):238-45. doi: 10.1016/s0006-291x(03)00124-4.

https://pubmed.ncbi.nlm.nih.gov/12604337/